Blackseed (Nigella sativa) Oil and its Active Ingredient, Thymoquinone, Suppress the Aggressive Phenotype of Breast Cancer Cells
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چکیده
منابع مشابه
Nigella sativa and its active constituent thymoquinone in oral health
In this review, we summarized published reports that investigated the role of Nigella sativa (NS) and its active constituent, thymoquinone (TQ) in oral health and disease management. The literature studies were preliminary and scanty, but the results revealed that black seed plants have a potential therapeutic effect for oral and dental diseases. Such results are encouraging for the incorporati...
متن کاملAnti-tumor properties of blackseed (Nigella sativa L.) extracts.
The objective of the present study was to evaluate the in vitro and in vivo anti-cancer effect of Nigella sativa L. seed extracts. The essential oil (IC50 = 0.6%, v/v) and ethyl acetate (IC50 = 0.75%) extracts were more cytotoxic against the P815 cell line than the butanol extract (IC50 = 2%). Similar results were obtained with the Vero cell line. Although all extracts had a comparable cytotoxi...
متن کاملA glance at black cumin(Nigella sativa) and its active constituent, thymoquinone, in ischemia: a review
Objective(s): Black cumin (Nigella sativa) belonging to Ranunculaceae family has a long history of medicinal use in various folk and traditional systems of medicine, including Iranian traditional medicine (ITM). These valuable medicinal seeds have been used traditionally against a variety of diseases such as dyspepsia, diabetes, headache, influenza and asthma. In addition, several scientific in...
متن کاملModes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells.
Our previous studies on active constituents of Nigella sativa have indicated that cell death induced by thymoquinone and alpha-hederin was dose- and time-dependent, in a range of four cancer cell lines. Both compounds elicited necrosis and apoptosis with a higher incidence of the latter induced by thymoquinone. As HEp-2 human laryngeal carcinoma cells were the most susceptible, we sought to bet...
متن کاملProtective effect of thymoquinone, the active constituent of Nigella sativa fixed oil, against ethanol toxicity in rats
Objective(s): Long term consumption of ethanol may induce damage to many organs. Ethanol induces its noxious effects through reactive oxygen species production, and lipid peroxidation and apoptosis induction in different tissues and cell types. Previous experiments have indicated the antioxidant characteristics of thymoquinone, the active constituent of Nigella sativa fixed oil, against biologi...
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ژورنال
عنوان ژورنال: American Journal of Undergraduate Research
سال: 2017
ISSN: 1536-4585,2375-8732
DOI: 10.33697/ajur.2017.010